Coach Chuck Pagano confirmed Monday that the quarterback would miss the Week 3 tilt versus the Cleveland Browns.
Ruling out Luck early in the week allows the team to move forward with fewer questions as they prep Jacoby Brissett to make his second start for the Colts.
After joining the team mere weeks ago, Brissett completed 22 of 40 passes for 267 yards, and threw an interception on the first pass of overtime in a 16-13 loss to the Arizona Cardinals. It was just the third career start for the second-year pro.